Date of Completion
Spring 5-1-2016
Project Advisor(s)
Akiko Nishiyama; Dennis Wright; Daniel Schwartz
University Scholar Major
Pharmacy Studies
Disciplines
Cellular and Molecular Physiology | Medicinal Chemistry and Pharmaceutics | Molecular and Cellular Neuroscience | Nervous System Diseases
Abstract
Gliomas, a type of brain tumor, can be difficult to treat and have a poor survival rate. One pathway that leads to glioma formation is excessive signaling by platelet derived growth factors (PDGF) through PDGF receptor α (PDGFRα). Through this research, I found that novel compounds that downregulate PDGFRα decrease proliferation of Oli-neu cells, an oligodendrocyte precursor cell model, and identified signaling pathways through which these compounds may exert their effect. Further investigation may identify targets for development of glioma treatments.
Recommended Citation
Sakya, Sagune, "Exploring the Effect of Novel Small Molecules on Oligodendrocyte Precursor Proliferation" (2016). University Scholar Projects. 27.
https://digitalcommons.lib.uconn.edu/usp_projects/27