Title

Loss of Vascular Early Response Gene Reduces Edema Formation After Experimental Stroke

Authors

Fudong Liu, University of Connecticut School of Medicine and Dentistry
L C. Turtzo, University of Connecticut School of Medicine and Dentistry
Jun Li, University of Connecticut School of Medicine and Dentistry
Neer Zeevi, University of Connecticut School of Medicine and Dentistry
Louise D. McCullough, University of Connecticut School of Medicine and Dentistry

Document Type

Article

Disciplines

Medicine and Health Sciences

Abstract

Vascular Early Response Gene (Verge) is an immediate early gene (IEG) that is up-regulated in endothelial cells in response to a number of stressors, including ischemic stroke. Endothelial cell lines that stably express Verge show enhanced permeability. Increased Verge expression has also been associated with blood brain barrier breakdown. In this study we investigated the role of Verge in ischemic injury induced by middle cerebral artery occlusion (MCAO) in both Verge knockout (KO) and wild type (WT) mice. Verge KO mice had significantly less cerebral edema formation after MCAO compared to WT mice. However, stroke outcome (infarct size and neurological deficit scores) evaluated at either 24 or 72 hours after stroke showed no differences between the two genotypes. Verge deletion leads to decreased edema formation after ischemia; however acute stroke outcomes were unchanged.

Comments

Originally published in :

Experimental & Translational Stroke Medicine 2012, 4:12 doi:10.1186/2040-7378-4-12

The electronic version of this article is the complete one and can be found online at: http://www.etsmjournal.com/content/4/1/12

PMID:

[PubMed]

PMCID:

PMC3403842

Recommended Citation

Liu, Fudong; Turtzo, L C.; Li, Jun; Zeevi, Neer; and McCullough, Louise D., "Loss of Vascular Early Response Gene Reduces Edema Formation After Experimental Stroke" (2012). UCHC Articles - Research. 111.
https://digitalcommons.lib.uconn.edu/uchcres_articles/111