Date of Completion
Spring 5-9-2010
Thesis Advisor(s)
George Kuchel
Honors Major
Physiology and Neurobiology
Disciplines
Cellular and Molecular Physiology | Physiology
Abstract
Detrusor underactivity (DU) increases susceptibility to urinary retention and accordingly further complicates the management of urinary incontinence. Bladder muscle stretch, a lack of estrogen, and aging are 3 notable DU risk factors. The aim of this research is to better characterize the changes in cellular composition of the bladder that result from these 3 risk factors to gain a better understanding of DU pathogenesis and pathobiology. This research focuses on the effects of a lack of estrogen while also providing an outline for determining the effects of bladder muscle stretch and aging on the cellular composition of the bladder.
Recommended Citation
Smith, Diane Holly, "Alterations in the Cellular Composition of the Mouse Bladder Following Ovariectomy, Partial Bladder Outlet Obstruction, and Aging" (2010). Honors Scholar Theses. 148.
https://digitalcommons.lib.uconn.edu/srhonors_theses/148