Date of Completion
Summer 8-28-2024
Thesis Advisor(s)
Steven Zinn; Sarah Reed
Honors Major
Animal Science
Abstract
Lipopolysaccharides (LPS) are a critical component of the cell wall in gram-negative bacteria and play a notable role in the host immune system's response to infection. The LPS challenge, involving the administration of exogenous bacterial LPS to replicate host immune response, provides insight into host responses to inflammatory diseases. Monitoring this response through various stress biomarkers such as serum cytokines, chemokines, white blood cell populations, rectal temperature, and cortisol concentrations enables the understanding of systemic metabolic changes and stress phenotyping. LPS research has the potential to make a significant contribution to the development of stress-resilient livestock. This is particularly important considering the growing environmental and microbial stressors, the increase in antimicrobial resistance, and the need for sustainable food animal production.
Recommended Citation
Medeiros, Mimosa, "Lipopolysaccharide Immune Challenge Stress Biomarkers in Livestock: A Review" (2024). Honors Scholar Theses. 1114.
https://digitalcommons.lib.uconn.edu/srhonors_theses/1114
