Date of Completion

Spring 5-29-2023

Thesis Advisor(s)

Joseph Loturco

Honors Major

Physiology and Neurobiology

Abstract

Ependymoma tumors are the third most common pediatric brain tumor. Tumor growth requires the formation of new blood vessels, known as angiogenesis, and interfering with tumor angiogenesis may be an approach to reduce tumor growth. In my thesis project, I will quantify blood vessel patterns within and nearby Supratentorial Ependymoma in a mouse model of this tumor type. I will compare vascularization within the tumors, in regions near tumors, and in the brain regions with no tumors. I will also determine whether CRISPR-mediated mutagenesis of genes expressed highly within the tumors alter angiogenesis.

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