Date of Completion
3-3-2020
Embargo Period
8-29-2020
Keywords
BipA, E. coli, Adaptation, Physiology
Major Advisor
Dr. David Benson
Co-Major Advisor
Dr. Victoria Robinson
Associate Advisor
Dr. Daniel Gage
Associate Advisor
Dr. Joerg Graf
Associate Advisor
Dr. Kenneth Campellone
Field of Study
Molecular and Cell Biology
Degree
Doctor of Philosophy
Open Access
Open Access
Abstract
BipA, also known as TypA, is a highly conserved protein originally identified in Salmonella typhimurium as a protein that is induced in response to bactericidal/permeability-inducing protein. Mutants lacking BipA exhibit a wide variety of phenotypes. Some of these phenotypes include: diminished pathogenicity, altered capsule biosynthesis, decreased resistance to antibiotics and antimicrobial peptides, as well as diminished growth at low temperatures. These data suggest that BipA affects multiple systems throughout the cell, suggesting that BipA plays a role in adaptation to various conditions within the cell. A similar role has been proposed for RelA although effecting transcription during adaptation rather than translation. I propose here that BipA is involved in the stringent response at the level of translation and may interact with RelA when conditions in the cell change.
Recommended Citation
Bova, Rebecca, "Characterizing the Role BipA Plays During Cellular Adaptation in Escherichia coli" (2020). Doctoral Dissertations. 2430.
https://digitalcommons.lib.uconn.edu/dissertations/2430