Daniel YuFollow

Date of Completion

Spring 5-1-2020

Project Advisor(s)

Elaine Choung-Hee Lee; Beth Taylor; Paul Thompson; Theodore Rasmussen

University Scholar Major

Exercise Science


Biochemistry, Biophysics, and Structural Biology | Cell and Developmental Biology | Kinesiology | Medicine and Health Sciences | Physiology


Statins are widely prescribed and used chronically, but we know little about the effects on long-term protein homeostasis during stress and aging. Our aim was to quantify the effect of statins on stress-induced protein damage. We administered atorvastatin in a dose-response curve in Caenorhabditis elegans under naïve control conditions and in conditions of hypertonic and heat stress known to induce muscle damage measurable as countable puncta in a polyglutamine aggregation model of damage. We observed that there is significant polyglutamine aggregation variability among worms at baseline and thus further study requires within experiment baseline controls, per worm. Our results are that statins exacerbate (p