Document Type



Medicine and Health Sciences


While the symptomology of underactive bladder (UAB) may imply a primary dysfunction of the detrusor muscle, insights into pathophysiology indicate that both myogenic and neurogenic mechanisms need to be considered. Due to lack of proper animal models, the current understanding of the UAB pathophysiology is limited, and much of what is known about the clinical etiology of the condition has been derived from epidemiological data. We hereby review current state of the art in the understanding of the pathophysiology of and animal models used to study the UAB.


Int Urol Nephrol. Author manuscript; available in PMC 2015 Jun 16. Published in final edited form as: Int Urol Nephrol. 2014 Sep; 46(0 1): S11–S21. Published online 2014 Sep 20. doi: 10.1007/s11255-014-0808-9 PMCID: PMC4469340 NIHMSID: NIHMS697983