Document Type



Life Sciences | Medicine and Health Sciences


Herpes simplex virus (HSV) encodes seven proteins necessary for viral DNA synthesis—UL9 (origin-binding protein), ICP8 (single-strand DNA [ssDNA]-binding protein), UL30/UL42 (polymerase), and UL5/UL8/UL52 (helicase/primase). It is our intention to provide an up-to-date analysis of our understanding of the structures of these replication proteins and how they function during HSV replication. The potential roles of host repair and recombination proteins will also be discussed.


Cold Spring Harb Perspect Biol. Author manuscript; available in PMC Nov 18, 2012. Published in final edited form as: Cold Spring Harb Perspect Biol. Sep 1, 2012; 4(9): a013011. Published online Sep 1, 2012. doi: 10.1101/cshperspect.a013011 PMCID: PMC3428768 NIHMSID: NIHMS414985