Document Type



Medicine and Health Sciences


In little more than 30 years, Lyme disease, which is caused by the spirochaete Borrelia burgdorferi, has risen from relative obscurity to become a global public health problem and a prototype of an emerging infection. During this period, there has been an extraordinary accumulation of knowledge on the phylogenetic diversity, molecular biology, genetics and host interactions of B. burgdorferi. In this Review, we integrate this large body of information into a cohesive picture of the molecular and cellular events that transpire as Lyme disease spirochaetes transit between their arthropod and vertebrate hosts during the enzootic cycle.


Nat Rev Microbiol. Author manuscript; available in PMC 2012 August 1. Published in final edited form as: Nat Rev Microbiol. 2012 January 9; 10(2): 87–99. doi: 10.1038/nrmicro2714 PMCID: PMC3313462 NIHMSID: NIHMS348239