Date of Completion


Embargo Period



Leighton Core, Judy Brown

Field of Study

Molecular and Cell Biology


Master of Science

Open Access

Campus Access


While the loss of genomic integrity is a widespread hallmark of cancer cells, little is known about the mechanisms that drive chromosome rearrangements and the sequence of events by which the genome increases in oncogenic potential. Here, we integrate data gathered at different points throughout the process of tumorigenesis, ranging from healthy/susceptible tissue to metastatic lesion with precancerous and neoplastic intermediates. We show through RNA sequencing, bisulfite sequencing, and targeted genomic sequencing that early changes in transcription and DNA methylation at the precancerous stage precede widespread genomic volatility and may predispose certain genomic regions to malignant chromosomal instability.

Major Advisor

Rachel O'Neill