Date of Completion
Spring 5-10-2024
Thesis Advisor(s)
Nicholas E. Leadbeater
Honors Major
Chemistry
Disciplines
Organic Chemistry
Abstract
This work investigates various key oxidation and oxidative functionalization reactions that occur using a bench-stable nitroxide and its oxoammonium nitrate salt congener. Such transformations include amidation of aldehydes to acyl azoles or hexafluoroisopropyl esters and oxidation of alcohols to ketones or aldehydes. These transformations are key, everyday reactions within organic chemistry, and the aim to make them cleaner and greener is essential to the future of chemistry. Novel compounds produced by these green methods will also be discussed, as well as the results of a scale-up protocol showing the efficacy of the reactions on a process chemistry level. As an additional component, the multistep synthesis of a novel triazolopyridine derivative will help to display the need for new, greener alternatives to chemical transformations.
Recommended Citation
Doherty, Katrina, "Cleaner, Green Oxidation Chemistry: Development of New Oxoammonium- and Nitroxide- Mediated Transformations" (2024). Honors Scholar Theses. 995.
https://digitalcommons.lib.uconn.edu/srhonors_theses/995