Date of Completion
Spring 5-1-2024
Thesis Advisor(s)
Na Li
Honors Major
Doctor of Pharmacy
Disciplines
Other Pharmacy and Pharmaceutical Sciences | Pharmaceutics and Drug Design
Abstract
The research of amorphous drug formulations is an emerging field of study, which offers a promising strategy to improve the oral bioavailability of poorly water-soluble drugs. A critical aspect of amorphous solubility is the measurement of particle size and light diffraction, which is measured using dynamic light scattering (DLS). DLS is a technique used to characterize the size of colloidal dispersions, where a laser beam illuminates a suspension of particles or molecules undergoing Brownian motion. In this experiment, a procedure was developed utilizing DLS to investigate the similarities and differences in light diffraction properties of particles among three different poorly water-soluble drugs. It was determined that there is a significant difference in light diffraction particles of different drugs despite the drug particles being the same size. As a quality control measure, particle size was manipulated and configured using different techniques to be similar among all three drugs. The drugs utilized in this experiment are atazanavir, lopinavir, and anacetrapib.
Recommended Citation
Casella, Sarah, "The Light Scattering Properties of Amorphous Nanoparticles Formed By Poorly Soluble Drugs" (2024). Honors Scholar Theses. 1047.
https://digitalcommons.lib.uconn.edu/srhonors_theses/1047