Document Type



Life Sciences


Evolutionary elaboration of tissues starts with changes in the genome and location of the stem cells. For example, GABAergic interneurons of the mammalian neocortex are generated in the ventral telencephalon and migrate tangentially to the neocortex, in contrast to the projection neurons originating in the ventricular/subventricular zone (VZ/SVZ) of the dorsal telencephalon. In human and nonhuman primates, evidence suggests that an additional subset of neocortical GABAergic interneurons is generated in the cortical VZ and a proliferative niche, the outer SVZ. The origin, magnitude, and significance of this species-specific difference are not known. We use a battery of assays applicable to the human, monkey, and mouse organotypic cultures and supravital tissue to identify neuronal progenitors in the cortical VZ/SVZ niche that produce a subset of GABAergic interneurons. Our findings suggest that these progenitors constitute an evolutionary novelty contributing to the elaboration of higher cognitive functions in primates.


Cell Rep. Author manuscript; available in PMC 2015 Jan 26. Published in final edited form as: Cell Rep. 2014 Dec 24; 9(6): 2139–2151. Published online 2014 Dec 11. doi: 10.1016/j.celrep.2014.11.026 PMCID: PMC4306459 NIHMSID: NIHMS653760

Included in

Life Sciences Commons