Date of Completion


Embargo Period



Blair T. Johnson; Dean G. Cruess

Field of Study



Master of Arts

Open Access

Campus Access


Sub-optimal antiretroviral adherence is a serious problem among people living with HIV (PLWH) that can lead to virologic rebound, resistance to medication regimens, and poor health outcomes. Emerging technologies allow for the detection of potential missed doses in real time as a possible point of intervention. Using these sensory technologies, this test of concept intervention trial was designed to target possible missed doses and initiate just-in-time self-regulation adherence counseling. The purpose of this study was to assess the acceptability, feasibility and potential efficacy of a just-in-time adherence counseling intervention using a Wisepill electronic pillbox device. Overall, there was trending evidence for greater medication adherence for those in the intervention condition (d=0.21). Additionally, the majority of participants found both the device and the intervention acceptable. However, the intervention had low feasibility. Only a small number (11.7%) of missed doses were able to be counseled. Thus, utilizing the Wisepill device for intervention initiation may not be the best way to use this device to increase medication adherence among PLWH. However, the opportunities that the Wisepill device and others like it afford have not yet been fully elucidated.

Major Advisor

Seth C. Kalichman