Growth hormone axis response following resistance exercise in lean men versus obese men

Date of Completion

January 2010


Health Sciences, Recreation




It has been suggested that obese individuals have a blunted GH response to spontaneous and stimulated growth hormone (GH) secretion. The present study was designed to examine the effects of a high volume whole body resistance acute exercise protocol on plasma glucose, ghrelin, GH, bioactive GH and cortisol between lean and obese sedentary men. Severity of obesity may be related to increasing alterations in endocrine responses related to the growth hormone axis. Ten obese (mean ± SD age: 20.8±2.1 height: 69.7±1.6 body mass: 108.7±15.9 body fat: 37.6±5.29) and nine lean (mean ± SD age: 20.1±2.1 height: 177.8±8.7 body mass: 71.7±5.8 body fat: 14.7±3.54) completed an acute resistance exercise protocol (6 exercises, 3 sets of 10 repetitions at 85–95% 10RM with 120s and 90s rest periods). Pre, Mid, Post and Recovery blood samples were collected. GH showed a significant increase in both the obese and lean groups. Glucose and insulin increased in both groups. Results suggest both obese and lean sedentary men performing a high volume whole body resistance acute exercise protocol with the same volumes across groups can elevate growth hormone levels. ^