Date of Completion


Embargo Period



Misinformation, vaccine, emotion, topic evolution, popularity

Major Advisor

Ross Buck

Associate Advisor

Leslie Snyder

Associate Advisor

Mark A. Hamilton

Field of Study

Communication Sciences


Doctor of Philosophy

Open Access

Open Access


In the digital age, true and false information can influence health-related decisions differently. It is important to monitor the dissemination of misinformation, understand public interests and develop persuasive messages. Two studies were conducted in order to meet these goals. Study 1 used computational methods to explore topic evolution and popularity in vaccine-related online messages. Topic modeling identified 14 topics in pro-vaccine messages (PVMs) and 12 topics in anti-vaccine messages (AVMs). PVMs that used personal stories received the highest number of shares, reactions, and comments. Pure scientific knowledge received the least attention. The most frequently appearing topic in AVMs was about child death. AVMs that discussed flu shots and government conspiracy were the most popular. Since 2016, even though more PVMs appeared online, AVMs were more popular and the comparative popularity of AVMs increased fast. AVMs that discussed vaccine damage were increasingly popular. Newly-emerged anti-vaccine topics (e.g. false rumors of CDC conspiracy) should be noted.

Based on Study 1’s results, Study 2 designed four PVMs and tested if these messages could increase HPV vaccine acceptability among parents who had not vaccinated their children. A total of 301 parents participated in an online experiment. SEM was used to analyze emotional and cognitive responses after the intervention. Results revealed that only the pro-organization message with low levels of emotions could increase vaccine acceptability. Anti-organization messages had no effect on the outcome. Political views and gender of parents could influence vaccine-related cognitive responses and eventually affected vaccine acceptability. Implications for message design were provided.